INS and myocardial infarction: Notably, although we showed that the expression levels of vector-encoded ciRS-7 are generally low, recent studies have utilized the exact same expression plasmid for studies of the influence of miR-7 on brain development, insulin secretion, and myocardial infarction.19, 23, 24 In addition, we investigated the idea that circRNAs equipped with a TuD motif could further improve miRNA suppression potential of TuDs.