RPE65 and choroideremia: The phenotype described in patients WVU: III-8 and GC4177: IV-1 resembles that observed in choroideremia (CHM), patients heterozygous for the p.Asp477Gly mutation in RPE65, some PRPH2 mutations, and the p.M216K mutation in RHO. 13, , –16 CHM, and RPE65- and RGR-dominant retinopathies affect initially the RPE due to the expression of their respective genes, and, therefore, are likely to have similar clinical features.