The incidence of pancreatic autoimmunity or LADA among women undergoing to ART is unknown (2.72% in our RM and RIF cohort), but it is known that LADA patients have more frequent need for insulin treatment than patients with type 2 diabetes: its early diagnosis and treatment definitely improve their metabolic control and could have a positive impact over their reproductive outcome. This evidence concerns the gene INS and type 2 diabetes mellitus.