We found that STZ induced sustained fasting hyperglycemia in rats (Figure 1A), low serum insulin levels (Figure 1B), and poor glucose response (Figure 1C), likely due to loss of pancreatic beta cells (Figure 1D) that led to a significantly reduced beta-cell mass, assessed 6 weeks after STZ treatment at which point the rats were sacrificed (Figure 1E). Here, INS is linked to Hyperglycemia.