Similarly, the density of ALDH1 was also increased in ALS cases (P = 0.0105) and in cases with MDD (P = 0.0021) but not SDD (P = 0.3026) in the ventral horns (Figure 2Q–T), but not in the lateral columns (Figure 2U–X). Here, ALDH1A1 is linked to amyotrophic lateral sclerosis.