Of note, not all HSPBs are consistently upregulated in ALS spinal cord (that is HSPB1 and 6), while HSPB5 and 8 are upregulated in patients with SDD, HSP16.2 is increased in ALS cases with MDD, underscoring the functional diversity of the different HSPB family members 16. Here, CRYAB is linked to amyotrophic lateral sclerosis.