HSPB1 and amyotrophic lateral sclerosis: In accordance with the motor neuron loss in ALS, fewer HSPB1+ motor neurons were observed in the ventral horns (data not shown) contributing to the decreased HSPB1 expression in ALS (P = 0.0384; Figure 3C) although differences could not be attributed to disease duration that is SDD (P = 0.2261) or MDD (P = 0.1640).