HSPB1 and amyotrophic lateral sclerosis: Overall, HSPB1 expression in the lateral tracts of ALS spinal cord was similar to controls (Figure 3I), however, in a small subset of ALS patients, many HSPB1+ astrocytes were observed (Figure 2J) and occasionally HSPB1 was highly expressed in the subpial region (Figure 3K,L).