TGFB1 and renal fibrosis: AT-II binding on the angiotensin II type 1 (AT1) receptor results in glomerular hypertension, which can promote further glomerular damage, proteinuria and activation of pro-inflammatory and profibrotic pathways.1,11,12 Transforming growth factor beta 1 (TGF-β1) has been described as the mediator that plays the main role in the developing process of renal fibrosis.