In our study, 112 differentially distributed proteins (69 upregulated and 43 downregulated) were characterized from ascitic fluid samples of HCC patients, including keratin 1 (KRT1), keratin 2 (KRT2), carbonic anhydrase 1 (CA1), and hepatocyte growth factor activator (HGFA). This evidence concerns the gene KRT2 and hepatocellular carcinoma.