The genetic locus associated with endometriosis risk on chromosome 1p36 (discussed above) overlaps completely with an association signal for ovarian cancer.79,92 The association signals are located in WNT4. 79,92 Subsequent follow-up functional studies show correlated association signals for endometriosis in this region regulate LINC00339 and CDC42 not WNT4,83 and one or both target genes may also play a role in ovarian cancer risk. This evidence concerns the gene CDC42 and ovarian carcinoma.