A large observational study showed that genetic variations inABCG5/8 associated with decreased levels of plasma low-density lipoprotein (LDL) cholesterol are protective against myocardial infarction but increase the risk of symptomatic gallstone disease, suggesting that there is an intrinsic link between these two diseases and that this link is based on the activity of ABCG5/8106. This evidence concerns the gene ABCG5 and myocardial infarction.