Its main function as a tumor suppressor is ras GTP-ase which de-activates RAS, thus preventing activation of the oncogenic RAS-RAF-MEK signaling cascade.TMEM127 is a negative regulator of mTOR, which is a PI3K kinase, shown to be activated in many human cancers and associated with increased cell proliferation, angiogenesis, and survival. Here, TMEM127 is linked to neoplasm.