Recent studies on LSD1 activity have therapeutic potential in cancer, which includes the finding of LSD1 that is necessary for the maintenance of acute myeloid leukemia containing mixed lineage leukemia translocations [120] and inhibition of LSD1 can reactivate the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [121]. The gene discussed is KDM1A; the disease is cancer.