PLCG2 and autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation: Since the PLCG2 mutation causing the S707Y substitution also provides the molecular basis of the germline monogenic autoinflammatory disorder APLAID, we compared the activity of PLCγ2S707Y to those of the two mutants causing the related disease PLAID, PLCγ2Δ19 and PLCγ2Δ20-22.