The first target of the AML multi-mutations is DNA methyltransferase 3A (DNMT3A), which is followed by mutations in the Fms-like tyrosine kinase 3 (FLT3), nucleophosmin 1 (NPM1), and/or isocitrate dehydrogenase 1 (IDH1) genes. Here, NPM1 is linked to acute myeloid leukemia.