Four variants [c.1393G>C (p.Gly465Arg) and c.2179G>A (p.Gly727Arg) in GLI3, c.360C>T (p.Ala120=) in CDKN2B and c.2794G>A (p.Val932Met) in PALB2] were identified in tumours that developed recurrence and in all cases were present both in primary and recurrent samples. Here, GLI3 is linked to neoplasm.