TIMP1 and lung cancer: Based on a recent investigation by our group demonstrating that TIMP-1 is released from lung cancer cells as part of the antiangiogenic impact of cannabinoids [25], in addition to previous findings revealing cisplatin to similarly induce TIMP-1 in lung cancer cells [26], we focused on the contribution of TIMP-1 to the antiangiogenic effect of CM from cisplatin-treated A549 and H358 cells on HUVECs.