In the pathogenesis of NAFLD&NASH in Figure 5, we identified eight genes having expression difference between normal liver cells and NAFLD&NASH, i.e., HIST2H2BE (p value ≤ 1.06 × 10−1), RFC5 (p value ≤ 1.5 × 10−2), HSPB1 (p value ≤ 6.6 × 10−2), ZNF480 (p value ≤ 1.0 × 10−2), TUBA1C (p value ≤ 3.48 × 10−1), RPL30 (p value ≤ 1 × 10−3), FRAT2 (p value ≤ 1.08 × 10−1), and TRMT1 (p value ≤ 5.33 × 10−1). The gene discussed is HSPB1; the disease is metabolic dysfunction-associated steatohepatitis.