In the hepatocarcinogenesis of NAFLD&NASH in Figure 2, we also identified eight genes with differences in expression between NAFLD&NASH and HCC, i.e., HIST2H2BE (p value ≤ 1.00 × 10−3), RFC5 (p value ≤ 1.00 × 10−3), HSPB1 (p value ≤ 1.00 × 10−3), ZNF480 (p value ≤ 1.00 × 10−3), TUBA1C (p value ≤ 1.00 × 10−3), RPL30 (p value ≤ 1.00 × 10−3), FRAT2 (p value ≤ 1.00 × 10−3), and ALDOB (p value ≤ 1.5 × 10−2). The gene discussed is HSPB1; the disease is metabolic dysfunction-associated steatohepatitis.