IGF2 and neoplasm: Furthermore, abnormal miR-122 can still be accumulated to cause the dysfunction of apoptosis through the dysregulation of TIMP1, and abnormal miR-29a can still be accumulated to cause the dysfunction of autoimmune through the dysregulation of IGF2, and abnormal miR-21 can still be accumulated to cause the dysfunction of metabolism through the dysregulation of ALDOB, which might facilitate tumor metastasis and invasion in HCC, as shown in Figure 4.