In the hepatocarcinogenesis of PBC&PSC in Figure 4, we also identified ten genes having differences in expression between PBC&PSC and HCC, i.e., HIST2H2BE (p value ≤ 1.00 × 10−3), RFC5 (p value ≤ 1.00 × 10−3), TIMP1 (p value ≤ 1.00 × 10−3), ZNF480 (p value ≤ 1.00 × 10−3), H3F3A (p value ≤ 1.00 × 10−3), RPL30 (p value ≤ 1.00 × 10−3), FRAT2 (p value ≤ 1.00 × 10−3), ALDOB (p value ≤ 7.2 × 10−2), IGF2 (p value ≤ 1.07 × 10−1), and RPL23A (p value ≤ 1.00 × 10−3). The gene discussed is RFC5; the disease is hepatocellular carcinoma.