In order to investigate the cellular mechanisms of NAFLD&NASH (or PBC&PSC) pathogenesis and NAFLD&NASH-associated (or PBC&PSC-associated) hepatocarcinogenesis in the liver cells of patients, we constructed the stochastic models of the genome-wide genetic and epigenetic network (GEN) in human cells based on molecular mechanisms, including TF regulations, miRNA repressions, DNA methylation of genes, and protein-protein interactions (PPIs). The gene discussed is TF; the disease is metabolic dysfunction-associated steatotic liver disease.