IGF2 and neoplasm: Therefore, we suggested that the dysregulation of miR-21, miR-29a, and miR-122 contributes to the dysregulation of TUBA1C, ALDOB, IGF2, and TIMP1, which might lead to tumor invasion and metastasis in the development of HCC, facilitating further aggressive tumor progression, as shown in Figure 8 with more detailed discussion in the sequel.