Most cellular mechanisms share some similarity to NAFLD&NASH progressing to HCC other than the dysfunction of the autoimmune response caused by the dysregulation of both H3F3A and RPL23A through abnormal miR-29a and miR-122 silencing, respectively, to facilitate the progression of PBC&PSC into HCC. The gene discussed is RPL23A; the disease is hepatocellular carcinoma.