Moreover, EGFR also represses TP53 to modulate ETS1 in the MAPK signaling pathway to promote dysfunction of metabolism and apoptosis through the mediation of FRAT2 and RPL30. In addition, the dysregulation of TUBA1C caused by abnormal miR-122 silencing and the dysregulation of ALDOB caused by both hypermethylation and abnormal miR-21 silencing might facilitate tumor metastasis. Here, FRAT2 is linked to neoplasm.