In this study, we established that the change in the miRNA expression profile of miR-21 (p value ≤ 1.00 × 10−3) results in a significant change in the gene expression profile of ZNF480 (p value ≤ 1.00 × 10−3) to progress from NAFLD&NASH to HCC, as shown in Figure 6. The gene discussed is ZNF480; the disease is metabolic dysfunction-associated steatohepatitis.