According to DNA methylation profiles in the normal liver cells and NAFLD&NASH, we found one gene that had undergone hypermethylation, i.e., HIST2H2BE (p value ≤ 2.05 × 10−1), and two genes that had undergone hypomethylation, i.e., RPL30 (p value ≤ 4.90 × 10−1) and TRMT1 (p value ≤ 4.40 × 10−1) in a comparison of normal liver cells with NAFLD&NASH cells. The gene discussed is RPL30; the disease is metabolic dysfunction-associated steatohepatitis.