Previous studies have demonstrated that a potential link between ATXN1 expression (both upregulation and downregulation) and cancer development in humans could regulate cell proliferation and the epithelial-mesenchymal transition of cells in various cancers [24, 25], but it remains unknown whether ATXN1 acts as a tumor suppressor or an oncogene. The gene discussed is ATXN1; the disease is neoplasm.