In addition, these oxidized crosslinks are reversible and can be reduced back to thiols or mercaptans, which completes the thiol–disulphide homeostasis.5 Disturbance of thiol/disulfide homeostasis in favor of disulfide has been shown to impact the disease pathogenesis.6 In various conditions such as ischemia, hypoxia, metabolic acidosis, and augmented OS, the structure of albumin alters its form to Ischemia-Modified Albumin (IMA). The gene discussed is ALB; the disease is ischemia.