Recently, we have demonstrated interplay between Ser208-phosphorylation and Ser190-O-GlcNAcylation of troponin T in ischaemic HF, linked to decreased activity of both PKCε and O-GlcNAcase (OGA) and increased O-GlcNAc transferase (OGT) activity (10). The gene discussed is OGA; the disease is hydrops fetalis.