The pathological hallmarks of Alzheimer’s disease (AD) are the presence of extracellular senile plaques containing amyloid β (Aβ) peptide, and intracellular neurofibrillary tangles of the microtubule-associated protein tau (Montine et al., 2012; Canter et al., 2016). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.