Notably, MALAT1 knockdown was found to attenuate the apoptosis of dopamine neurons in the MPTP-induced PD mouse model and miR-124 overexpression countered this effect, which suggests that MALAT1 induces apoptosis in the PD model by sponging endogenous miR-124 (Liu et al., 2017). This evidence concerns the gene MALAT1 and Parkinson disease.