Faghihi et al. (2008) reported BACE1-AS, a conserved antisense transcript of BACE1, which is the first regulatory ceRNA described in AD pathogenesis; BACE1-AS was shown to upregulate the BACE1 mRNA level by forming a stabilizing duplex with it and thereby enhancing BACE1 protein levels. Subsequent work from this group demonstrated that BACE1-AS regulates BACE1 mRNA levels by masking the binding site for miR-485-5p (Faghihi et al., 2010; Roberts et al., 2014), i.e., by functioning as a ceRNA. The gene discussed is BACE1; the disease is Alzheimer disease.