In AD patients, positron emission tomography (PET) scanning using specific ligands for TSPO have demonstrated increased binding in many cortical areas, indicative of increased TSPO expression (Cagnin et al., 2001; Yasuno et al., 2008, 2012; Venneti et al., 2009; Zimmer et al., 2014). This evidence concerns the gene TSPO and Alzheimer disease.