According to the univariate logistic regression analysis, the presence of IL28B rs8099917 TG SNP reduces the chances of HCC more than fivefold, and IL28B rs12979860 TT SNP more than sevenfold (OR = 0.1786, p = 0.0333 and OR = 0.1389, p = 0.0231, respectively). Here, IFNL3 is linked to hepatocellular carcinoma.