Tian et al. were identified by three mutations, G270A (Glu32Lys), G378A (Glu68Lys), and G390A (Glu72Lys) in the NKX2.5 gene in a Chinese family with atrial septal defect (ASD) [24]. The gene discussed is NKX2-5; the disease is Abnormal cardiac septum morphology.