NKX2-5 and coronary artery disorder: In order to clarify whether the somatic NKX2.5 mutations play an important role in Iranian pediatric patients with CHD, we screened NKX2.5 gene mutations in peripheral blood from 105 sporadic patients with different CHD phenotypes and compared to 92 healthy control individuals using polymerase chain reaction-single stranded conformation polymorphism (PCR-SSCP) and DNA sequencing approaches.