SPP1 and myeloid sarcoma: One of them, leukocyte infiltration represented by chemokine (C-X-C motif) ligand 13 (CXCL13), CXCL10 and MMP-9, is possibly associated with future risk of MS, while the other, represented by osteopontin and chitinase-3-like protein 1 (CHI3L1), suggests tissue damage-related inflammation [47].