It was showed not only by transcriptional profile with up-regulation of basal regulators (especially TP63) and markers, and down-regulation of mature luminal and luminal progenitor regulators and luminal markers, including moderate decrease in the expression of lineage defining marker EPCAM and increase in tumor-initiating cell marker PROCR, but also by induction of epithelial-to-mesenchymal like transition observed as increased number of mesenchymal-type cells in A5 and D5 media, as described previously [34]. Here, PROCR is linked to neoplasm.