FUS and amyotrophic lateral sclerosis: Morphology and distribution of FUS inclusions vary among the CNS of different neurodegenerative conditions, with FUS inclusions reportedly being nuclear in Huntington’s disease (Doi et al., 2008) but primarily cytoplasmic in ALS and FTLD (King et al., 2015, Mackenzie et al., 2011), with some nuclear retention in even the most affected neurons with FUS inclusions (Munoz et al., 2009, Neumann et al., 2009, Rademakers et al., 2010).