In parallel with the analysis using isogenic PARK2−/− iPSCs (Figures 1 and S1), we established a robust and well-controlled in vitro culture system and demonstrated several PD-related phenotypes, including neurite abnormalities, elevated oxidative stress, and apoptosis in PARK2- and PARK2−/−-DA neurons (Figures 1, S2, and S3B). The gene discussed is PRKN; the disease is Parkinson disease.