ESR1 and metabolic dysfunction-associated steatotic liver disease: To explore the potential role of sex hormones in regulating the sexually dimorphic NAFLD genes and pathways identified, we tested the sex-specific liver and adipose tissue key driver subnetworks for enrichment of known target genes of estrogen receptors (ESR1, ESRRA, ESRRB, and ESRRG) and androgen receptor (AR) based on FANTOM5 transcription factor regulatory networks [44] from matching tissues.