An increasing number of studies have found various miR-200b targets, including ZEB2, PKCα, and Bmi-1, which are expressed in gastric adenocarcinoma, pituitary tumors, and prostate cancer, respectively.23,36,37 Therefore, we consider that other miR-200b-targeted proteins may play a role in the functional effects caused by miR-200b on HCC, and also lead to the upregulations of E-cadherin and Snail and vimentin. The gene discussed is BMI1; the disease is Familial prostate cancer.