HMGB3 and leukemia: In leukemia, Petit et al discovered an oncogenic NPU98-HMGB3 fusion protein.28 HMGB3 also functions in the progression of colorectal cancer by regulating the Wnt/β-catenin pathway16 and overexpression is related with worse prognosis in gastric adenocarcinoma.13 In this study, we analyzed HMGB3 expression in HCC.