In this study we found that 9 ACE2 polymorphic loci were respectively correlated with only one type of dyslipidemia, including higher LDL-C (rs1978124 and rs233575), lower HDL-C (rs2285666, rs4646142 and rs4646155) and higher TC (rs2074192, rs4240157, rs4646156 and rs4830542). Here, ACE2 is linked to metabolic syndrome.