TRPC3 and intervertebral disk degenerative disorder: The result of the evaluation indicated that trp3 polymorphism was not associated with IDD risk in both gender (as shown in Fig. 2b and Table 4, for male subgroup, trp3 positive versus trp3 negative: ORs = 1.30, 95%CI = 0.77–2.17, P = 0.322; heterogeneity test χ2 = 11.30, P < 0.10, I2 = 46.90%; for female subgroup, trp3 positive versus trp3 negative: ORs = 1.11, 95%CI = 0.62–2.01, P = 0.725; heterogeneity test χ2 = 1,64, P > 0.10, I2 = 0.00%).