Sterol regulatory element binding proteins (SREBPs) are members of a transcription factor family that control the expression of genes important for the uptake and synthesis of cholesterol, fatty acids, and phospholipids.30 Three isoforms of SREBPs (SREBP‐1a, SREBP‐1c, and SREBP‐2) are encoded by SREBF‐1 and SREBF‐2 respectively.30, 31, 32 Early studies focused on the effect of SREPBs on lipid metabolism, whereas recent studies explored the role of SREBPs in cancer. The gene discussed is SREBF2; the disease is cancer.