A previous study has reported that highly proliferative HNSCC cells possessed up‐regulated NEDD8 conjugation and MLN4924 cooperating with TRAIL‐augmented apoptosis possibly through facilitating c‐FLIP degradation in HNSCC cells.29 Most recently, Vanderdys et al30 found that Pevonedistat suppressed and radiosensitized HNSCC through inactivating CRL4‐CDT2 and DNA re‐replication. Here, NEDD8 is linked to head and neck squamous cell carcinoma.