The dysfunction of CRL, such as the elevated CRL neddylation modification, contributes to carcinogenesis and cancer progression.8 Recently, the neddylation pathway, including NAE, UBC12 and NEDD8 itself, has been frequently reported to be hyperactivated in several human cancers and indicates an unfavourable prognosis, highlighting the neddylation‐CRL pathway as an attractive anticancer target.9, 10, 11, 12, 13. This evidence concerns the gene UBE2M and cancer.