American scholar Kladney et al performed subtractive hybridization in liver cDNA libraries of healthy individuals and patients with acute adult giant cell hepatitis in 2000 and found that the mRNA expression in patients with adult giant cell hepatitis was specifically increased.53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63 The mRNA encodes a protein GP73 containing 401 amino acids, and its relative molecular mass is 4.5 × 104. The gene discussed is GOLM1; the disease is neonatal hemochromatosis.