Although accumulating studies indicate that abnormal GP73 expression is associated with tumour progression by interacting with the microenvironment, and GP73 has been regarded as a potential diagnostic marker for HCC, the diagnosis accuracy of GP73 in cirrhosis and HCC distinguishment is worthy discussed.20, 22, 187 Although some studies found that ELISA result did not show a significant elevation of serum GP73 in HCC groups compared with that in liver cirrhosis groups. This evidence concerns the gene GOLM1 and neoplasm.