GOLM1 and cirrhosis of liver: Block et al used glycoproteomics to find that GP73 serum levels in American cornfields with HCC in 2005 were significantly higher than those without HCC, and GP73 levels in patients with HCC were significantly higher than those in patients with colon metastases and HBV infection.183 Marrero et al detected GP73 serum levels in 352 liver cancer patients, liver cirrhosis patients and healthy subjects using Western blot (Figure 2).