NTRK1 and acute myeloid leukemia: Treatment of AML cell line, MOLM-14 cells with 2.5 μM OP449 or 1 nM AC220 alone, a small molecule of the receptor tyrosine kinase inhibitor, resulted in cell viability reduced by 58 and 75%, respectively, and the combination of OP449 and AC220 synergistically reduced cell growth by almost 96%: The combination of OP449 and AC220 has a novel therapeutic efficacy for treatment of CML and AML (Agarwal et al. 2014).