CIP2A and neoplasm: Dense foci formation on a monolayer of HeLa cells transfected with CIP2A.1-targeted siRNA abrogated cell foci formation 10 days after transfection, and HeLa cells transfected with CIP2A-targeted siRNA reduced overall tumor size in xenograft mouse model, resulting in significant inhibition of tumor weight (Junttila et al. 2007; Böckelman et al. 2012).