These analyses revealed that the diffuse and LF types of 53BP1 expression were frequently co-localized with DNA-PKcs expression in UC cells, in association with a loss of RAD51 expression, reduced p16ink4a levels and p53 overexpression; these changes showed tumor progression-related increases in severity, such as UP-LGUC-HGUC. This evidence concerns the gene TP53BP1 and neoplasm.