These S-HSP90 interacting proteins include co-chaperones previously shown27 to participate with HSP90 into the formation of epichaperome networks in cancer, such as HSP organizing protein (HOP, also known as stress-inducible phosphoprotein 1, STIP1), activator of HSP90 ATPase homolog 1 (AHA1, also known as AHSA1), HSC70 (heat shock cognate 70 kDa protein, the constitutively expressed HSP70 paralogue also known as HSPA8 and HSP7C) and its co-chaperone HSP110 (heat shock 105 kDa/110 kDa protein 1) (Fig. 1e). The gene discussed is HSP90AA1; the disease is cancer.