HSP90AA1 and Parkinson disease: Previous work has shown that treatment with PU-H71 rescues the axon growth retardation caused by overexpression of the LRRK2 G2019S mutation in neurons derived from LRRK2 G2019S transgenic mouse brains15, suggesting stable HSP90-chaperome networks as a more general mechanism used by neurons to regulate pathologic proteome stress in PD.