TGFB1 and allergic disease: However, only liposome-encapsulated T289-Per a 9 and T167-Per a 9 induced the expression of immunosuppressive cytokine genes (IL-10, TGF-β, and IL-35 for L-T289-Per a 9, and IL-10 and TGF-β for L-T167-Per a 9) and increment of IDO1, which indicated that the mechanisms of allergic disease suppression and the reversal of tissue remodeling induced by these two vaccines occurred via generation of regulatory lymphocytes.