However, only liposome-encapsulated T289-Per a 9 and T167-Per a 9 induced the expression of immunosuppressive cytokine genes (IL-10, TGF-β, and IL-35 for L-T289-Per a 9, and IL-10 and TGF-β for L-T167-Per a 9) and increment of IDO1, which indicated that the mechanisms of allergic disease suppression and the reversal of tissue remodeling induced by these two vaccines occurred via generation of regulatory lymphocytes. Here, IDO1 is linked to allergic disease.