APOB and abetalipoproteinemia: This gene is a strong candidate for harboring associations with LDL: MTTP encodes microsomal triglyceride transfer protein, which has been shown to involve in lipoprotein assembly; mutations in MTTP cause abetalipoproteinemia, a rare disease characterized by low levels of apolipoprotein B and LDL cholesterol; and MTTP is a potential pharmacological target for lowering LDL cholesterol levels40.