Similarly, GFP-sorted HepG2 cells expressing GFP-BMAL1 showed reduced HNF4α, while GFP-sorted Hepa-1c1c7 cells expressing GFP-HNF4α showed reduced Bmal1 mRNA abundance, confirming an inverse correlation between HNF4α and BMAL1 in the context of HCC (Supplementary Fig. 2c, d). Here, HNF4A is linked to hepatocellular carcinoma.