HNF4A and liver cancer: HepG2 spheroids infected with a lentiviral construct for BMAL1 showed reduced HNF4α expression (Supplementary Fig. 2a), while Hepa-1c1c7 spheroids infected with an HNF4α-containing vector showed reduced BMAL1 expression in synchronized organoid cultures (Supplementary Fig. 2b), suggesting an inverse relationship between BMAL1 and HNF4α in liver cancer cells.