HepG2 spheroids infected with a lentiviral construct for BMAL1 showed reduced HNF4α expression (Supplementary Fig. 2a), while Hepa-1c1c7 spheroids infected with an HNF4α-containing vector showed reduced BMAL1 expression in synchronized organoid cultures (Supplementary Fig. 2b), suggesting an inverse relationship between BMAL1 and HNF4α in liver cancer cells. This evidence concerns the gene BMAL1 and liver cancer.