CCND1 and hepatocellular carcinoma: Since P2-HNF4α expression results in an increase in cytoplasmic P1-HNF4α (as does SRC-induced phosphorylation), circadian repression in the nucleus of MYC, CCND1, CCND1, among other genes normally repressed in a healthy liver by P1-HNF4α appears to be reduced in HCC.