CCL17 and neoplasm: Utilising a cut-off of cytokines, which were upregulated at least 1.5-fold following KD mediated by both anti-GRHL3 shRNAs, we found that the only cytokine to be significantly upregulated (Fig. 1h, and Fig. S1G) was the thymus and activation-regulated chemokine (TARC), a paracrine signalling molecule known to be involved in promoting tumour proliferation, chemotaxis, inflammation and platelet activation, as well as being implicated in promoting the severity and progression of numerous skin pathologies.