GRHL3 also plays an important role in tumour suppression; mice with conditional deletion of Grhl3 in adult epidermis (subsequent to barrier formation) survive minor regression of the preformed barrier10, however, these mice develop spontaneous skin tumours when aged and show increased susceptibility to chemical-induced squamous cell carcinomas (SCC)11,12. Here, GRHL3 is linked to squamous cell carcinoma.