As SAMHD1 modulates efficacy of both clofarabine and fludarabine in THP-1 cells [8], we assessed whether SAMHD1 expression would have additional effects in patients receiving clofarabine or fludarabine in addition to HDAC-containing AML therapies by statistically evaluating interactions with SAMHD1. This evidence concerns the gene SAMHD1 and acute myeloid leukemia.