As shown in Figure 1, FBXO1 (HR = 1.39 95%CI: 1.12–1.72, P=0.0025), FBXO31 (HR = 1.37 95%CI: 1.10–1.69, P=0.0040), SKP2 (HR = 1.85 95%CI: 1.49–2.30, P=0.0008), and FBXO5 (HR = 1.65 95%CI: 1.33–2.05, P=0.0004) were significantly associated with worse OS in all BC patients (Figure 1A–D). The gene discussed is SKP2; the disease is breast cancer.