Univariate analyses shown in Tables 3 and 4 revealed that gender, age, TNM, differentiation, DOI were not significantly associated with OS and DFS (P>0.05), but lymph node metastasis (OS and DFS: P<0.0001), WPOI (OS and DFS: P=0.031), Ki67 expression in TCs at CT (OS: P=0.0395; DFS: P=0.046), and FLCs at IF (OS:P=0.0396; DFS:P=0.0445) presented to be a risk factor for OS and DFS of OSCC patients. Here, MKI67 is linked to metastatic malignant neoplasm in the lymph nodes.