From the results of the present study, it can be seen that the proportion of carriers with mutant T allele in rs774320676 locus and G allele in rs928508030 locus of CTSS in study group was significantly higher than in control group (P<0.05), indicating that the rs774320676 mutant T allele and the rs928508030 G allele of CTSS were risk factors for acute atherosclerotic cerebral infarction. Here, CTSS is linked to brain infarction.