Since we know that chronic cortisol exposure eventually induces myocardial hypertrophy, focal fibrosis (Johansen et al., 2011a) and impairs cardiac function (Johansen et al., 2017) in rainbow trout, it is tempting to speculate that a failure to persistently produce and secrete BNP with prolonged cortisol exposure makes the heart vulnerable to the harmful effects of cortisol on cardiac remodelling and function. The gene discussed is NPPB; the disease is cardiac hypertrophy.