Prior to association with AD, homozygous or compound heterozygous mutations in TREM2 had been identified in a disease called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) or Nasu‐Hakola disease (Bianchin et al, 2006). The gene discussed is TREM2; the disease is Nasu-Hakola disease.