Further study of reporter cells expressing WT TREM2, TREM2 R47H TREM2 R62H, or a putatively frontotemporal dementia (FTD) variant (TREM2 T96K) shows that the TREM2 AD variants R47H and R62H reduced NFAT activation whereas the FTD variants TREM2 T96K activated NFAT signaling at similar level then TREM2 (Fig 5B). This evidence concerns the gene TREM2 and frontotemporal dementia.