Conditioned media from transiently transfected HEK 293 cells expressing the soluble ectodomains of (i) human TREM2 fused to the Fc domain of human IgG4(sTREM2‐Fc), (ii) AD‐associated TREM2 variants (sTREM2‐R47HFc,sTREM2‐R62H), (iii) mouse TREM2 (sTrem2‐FC) or (iv) Fc control was incubated with fAβ. This evidence concerns the gene TREM2 and Alzheimer disease.