Another group showed that AD mice Trem2 R47H heterozygous reduced myeloid cell responses to amyloid deposition and reduction in proliferation and CD45 expression around plaque (Cheng‐Hathaway et al, 2018).These data present a conundrum given that we showed kinetics of binding of the R47H and WT TREM2 to Aβ are indistinguishable. This evidence concerns the gene TREM2 and Alzheimer disease.