IL2RA and extranodal nasal NK/T cell lymphoma: Here we describe several major findings: (1) LMP1 acts via the MAPK/NF-κB pathway to up-regulate IL-2Rα in NKTCL, (2) IL-2Rα overexpression promotes NKTCL cell proliferation and cell cycle progression without affecting apoptosis, and (3) IL-2Rα overexpression correlates positively with chemoresistance in NKTCL cells, and anti-IL-2Rα antibody can restore chemosensitivity.