GPX2 and neuroblastoma: The effect of oxidative stress decreasing the global levels of 5-hmC and modulating the genomic hydroxymethylation profile was demonstrated by Delatte and coworkers [129] in SY5Y human neuroblastoma cell line exposed to buthionine sulfoximine, and in colon epithelia of mice depleted for GPx1 and GPx2, both situations leading to increased levels of peroxides.